We are happy to announce that the first EuroNeurotophin Early Stage Researcher has defended her PhD successfully. Mirjana Antonijević (ESR6) had her PhD Defence on November 30th, 2021 on her research project on In silico screening and Hit to lead development of small molecules neurotrophin receptors ligands.
Over the course of the project Mirjana's project focused on in silico screening of UNICAEN chemical library to identify hit molecules as ligands for neurotrophin receptors. In silico data was evaluated along with a high-throughput screening of the chemical library. Selected hit molecules were subjected to the study of hit to lead optimization, with an aim to better understand the molecular patterns involved in target-ligand interactions. Additionally, these studies were expanded by the physicochemical optimization of the selected hit compounds. The final lead compounds have been fluorescently labeled for in vivo bioimaging studies.
We would like to congratulate Mirjana and wish her all the best for the future.