Early Stage Researchers
14 Early Stage Researchers have been recruited to the EuroNeuroTrophin network to be trained in the discovery of small molecule neurotrophin mimetics as candidate therapeutic agents for neurodegeneration and neuro-inflammation.
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ESR1: Daniele Narducci
Synthesis of dehydroepiandrosterone (DHEA) derivatives substituted by five or six membered-17-spiro substituents. Host: National Hellenic Research Foundation, Institute of Chemical Biology |
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ESR2: Alessia Latorrata
Synthesis of dehydroepiandrosterone (DHEA) derivatives substituted by three membered-17-spiro substituents. Host: National Hellenic Research Foundation, Institute of Chemical Biology |
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ESR3: Athanasios-Alexandros Tsengenes
Computer-aided design and optimization of neurotrophin small molecule mimetics Host: HITS gGmbH, Molecular and Cellular Modeling Group |
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ESR4: Christina Athanasiou
Modelling of mechanistic effects of neurotrophin modulators Host: HITS gGmbH, Molecular and Cellular Modeling Group |
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ESR5: Federica Carucci
X-Ray crystal structure determination of neurotrophin Receptors in complex with small molecules to drive receptor-based drug design. Host: University of Siena, Department of Biotechnology, Chemistry and Pharmacy |
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ESR6: Mirjana Antonijević
In silico screening and Hit to lead development of small molecules neurotrophin receptors ligands. Host: Université de Caen Normandie, UFR des Sciences Pharmaceutiques, Centre d'Etudes et de Recherche sur le médicament de Normandie |
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ESR7: Paolo Giaccio
Isolation of a new natural neurotrophin mimetics from marine microorganisms. Host: National and Kapodistrian University of Athens, Faculty of Pharmacy, Department of Pharmacognosy and Chemistry of Natural Products |
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ESR8: Canelif Yilmaz
Evaluation of small molecule neurotrophin mimetics in models of neurodegeneration and neuroinflammation Host: Technische Universität Dresden, Faculty of Medicine, Department of Clinical Pathobiochemistry |
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ESR9: Ana Aragón
Development of Human Cell-Based Models for study of Blood Brain Barrier Molecular Permeability Host: University of Sheffield, Sheffield Institute for Translational Neuroscience (SITraN) |
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ESR10: Débora Pita
Cell-Based Models for Neurotrophic Therapeutic Testing Host: UV University of Amsterdam, Center for Neurogenomics and Cognitive Research |
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ESR11: Thanasis Rogdakis
Evaluation of microneurotrophins activity on neurotrophin receptors and their role in signalling, in in vitro and in vivo neurodegenerative conditions, such as Alzheimer’s Disease . Host: Foundation for Research and Technology Hellas, Institute of Molecular Biology and Biotechnology |
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ESR12: Despoina Charou
In vitro and in vivo effects of new synthetic and natural compounds on neural stem cells and adult neurogenesis in Alzheimer’s Disease . Host: Foundation for Research and Technology Hellas, Institute of Molecular Biology and Biotechnology |
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ESR13: Evangelia Thanou
Investigation of the potency of small molecule mimetics of neurotrophins to rescue the reduction in synapse number and the aberrant synapse proteome in mouse models of Alzheimer’s Disease . Host: UV University of Amsterdam, Center for Neurogenomics and Cognitive Research |
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ESR14: Marco Destro
Discovery of new neurotrophin mimics using high-through put screening in amyotrophic lateral sclerosis (ALS) patient-derived in vitro models, and taking forward hit compounds into in vivo models. Host: University of Sheffield, Sheffield Institute for Translational Neuroscience (SITraN) |
