Results

In EuroNeurotrophin, we will disseminate our results mainly via scientific publications and conference presentations. However, we will publish articles in magazines and newspapers, and document our progress in reports to the European Commission.

We will update our list of contributions to publications, presentations and received media coverage on a regular basis over the course of the project.

Scientific Publications

• Neurosteroids as regulators of neuroinflammation
  Yilmaz, C., Karali, K., Fodelianaki, G., Gravanis, A., Chavakis, T., Charalampopoulos, I., & Alexaki, V. I. (2019). Neurosteroids as regulators of neuroinflammation. Frontiers in Neuroendocrinology, Volume 55, October 2019, 100788. DOI: https://doi.org/10.1016/j.yfrne.2019.100788
  
  
• DHEA inhibits leukocyte recruitment through regulation of the integrin antagonist DEL-1
  Ziogas, A., Maekawa, T., Wiessner, J. R., Le, T. T., Sprott, D., Troullinaki, M., ... & Sperandio, M. (2020). DHEA inhibits leukocyte recruitment through regulation of the integrin antagonist DEL-1. The Journal of Immunology, 204(5), 1214-1224. DOI: https://doi.org/10.4049/jimmunol.1900746 

Posters

• 22-23.03.2021 | Online | NHRF
  Synthesis in Drug Discovery and Development Virtual Symposium
  ”Synthesis of new DHEA 17-spyro-cyclopropyl derivatives with Neurotrophic, Neuroprotective and Anti-Inflammatory activity” Flash poster presentation by Alessia Latorrata (ESR2)
  
  
• 21-23.08.2019 | Nottingham, UK | UNICAEN
  27th Annual GP2A Medicinal Chemistry Conference
  “In silico screening and development of small molecules neurotrophin receptors ligands” Mirjana Antonijević (ESR6) received best poster award
  
  
• 20-22.02.2019 | Paris, FR | UNICAEN
  YRFM -Young Research Fellows Meeting, Annual meeting organised by UNICAEN
  “In silico screening and Hit to lead development of small molecules neurotrophin receptors ligands” Mirjana Antonijević (ESR6)
  
  
• 14-16.10.19 | FORTH Patras, EL | FORTH
  FORTH Retreat, 12th FORTH Scientific Retreat organised by FORTH
  "Identifying novel neurotrophin analogs: from structural interventions to biological selectivity to promote neuroprotection and neurogenesis" Thanasis Rogdakis (ESR11), Despoina Charou (ESR12), A. Gravanis
  
  
• 22-24.07.2019 | Kloster Schöntal, DE | HITS
  DKFZ-ZMBH alliance retreat
  - “Computer-Aided Drug Design of Small-Moleculeneurotrophin Mimetics” Athanasios-Alexandros Tsengenes (ESR3)
  - “Simulations of the TrkA Receptor to Elucidate the Mechanism of Action of Neurotrophin Mimetics” Christina Athanasiou (ESR4)
  
  
• 07-10.05.2019 | Heraklion, EL | UNICAEN
  EMBO Workshop Cell biology of the neuron: Polarity, plasticity and regeneration
  
  
• 05-06.09.2019 | Zappeion Conference & Exhibition Center, Athens, EL | NHRF, HITS
  EFMC-YSMC’19, 6th EFMC Young Medicinal Chemist Symposium, Conference poster presentations by
  - “Design and Synthesis of Dehydroepiandrosterone-Based Neurotrophinmimetics” Daniele Narducci (ESR1)
  - “Synthesis and biological evaluation of dehydroepiandrosterone 17-spiro-cyclopropyl derivatives with neurotrophin and neuroprotective activity” Alessia Latorrata (ESR2) won poster prize
  - “Computer-Aided Drug Design of Small-Moleculeneurotrophin Mimetics” Athanasios-Alexandros Tsengenes (ESR3)
  - “Simulations of the TrkA Receptor to Elucidate the Mechanism of Action of Neurotrophin Mimetics” Christina Athanasiou (ESR4)
  
  
• 05.07.2019 | Caen, FR | UNICAEN
  Normandy Doctoral School of Chemistry Day
  ” Identification and development of small molecules neurotrophin receptors ligands” Mirjana Antonijević (ESR6)
  
  
• 04-06.10.2019 | IMBB – FORTH, EL, FORTH
  28th meeting of the Hellenic Society of Neuroscience
  "Identifying novel neuro-trophin analogs: from structural interventions to biologi-cal selectivity to promote neuroprotection and neuro-genesis" Thanasis Rogdakis (ESR11), Despoina Charou (ESR12), A. Gravanis .
  
  
• 01-05.09.2019 | Peniche, PT | NKUA
  XVI International Symposium on Marine Natural Products, XI European Conference on Marine Natural Products
  "Marine-derived microorganisms as potential sources of neurotrophin mimetics for the tratment of neurodegeneretion and neuroinflammation" Paolo Giaccio (ESR7)
  
  
• 01-05.09.2019 | Zappeion Conference & Exhibition Center, Athens, EL | NHRF, HITS
  EFMC-ASMC'19, 8th EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry
  - “Design and Synthesis of Dehydroepiandrosterone-Based Neurotrophinmimetics” Daniele Narducci (ESR1)
  - “Synthesis and biological evaluation of dehydroepiandrosterone 17-spiro-cyclopropyl derivatives with neurotrophin and neuroprotective activity” Alessia Latorrata (ESR2)
  - “Computer-Aided Drug Design of Small-Moleculeneurotrophin Mimetics” Athanasios-Alexandros Tsengenes (ESR3)
  - “Simulations of the TrkA Receptor to Elucidate the Mechanism of Action of Neurotrophin Mimetics” Christina Athanasiou (ESR4)

Presentations

• 26.02.2021 | Online | NHRF
  18th Hellenic Symposium on Medicinal Chemistry
  "Neurotrophic, neuroprotective and anti-inflammatory activity of new synthet-ic Dhea 17-spiro-cyclopropyl derivatives” by Alessia Latorrata (ESR2)
  

• 28.11.2019 | Besançon, DE | UNICAEN
  Workshop about the development of multi-target directed ligands for the treatment of Alzheimer disease.
  “Polypharmacology of 5-HTs receptors in Alzheimer's Disease: An illustration of CERMN research facilities” C. Rochais
  
  
• 22-24.07.2019 | Kloster Schöntal, DE | HITS
  DKFZ-ZMBH alliance retreat
  “Computer-Aided Drug Design of Small-Moleculeneurotrophin Mimetics” Athanasios-Alexandros Tsengenes (ESR3)
  
  
• 20.11.2019 | Paris, DE | UNICAEN
  8th meeting of the Foundation Alzheimer
  “The design of multi-target drug candidates with potential therapeutic interest against Alzheimer’s disease” C. Rochais
  
  
• 10.05.2019 | Hong Kong Baptish university, Hong Kong, ROC | VUA
  Seminar presentation on Proteomics analysis of neurodegenerative diseases Ka Wan Li
  
  
• 08.11.2018 | BioCity, Glasgow, UK | ACS
  ELRIG seminar
  "Recent developments in the design of biological 3D structures to support and drive translational research into Drug Discovery and Drug Development"
  
  
• 26-27.09.2019 | KANAL Pombidou Centre, Brussels, BE | FORTH
  Falling Walls Lab, in the context of EU Research and Innovation Days
  “Breaking the wall of dementia” Thanasis Rogdakis (ESR11)
  
  
• 05.09.2019 | Strasbourg, FR | UNICAEN
  Seminar presentation at the Université de Strassbourg
  "Application du concept de polypharmacologie au design du donécopride et d’autres MTDL" C. Rochais
  
  
• 04-06.10.2019 | IMBB – FORTH, EL, FORTH
  28th meeting of the Hellenic Society of Neuroscience Symposium (S9) “Symposium 9: Euroneurotrophin: small molecule neurotophin mimetics” organised by T. Calogeropoulou 
  ”EuroNeurotrophin: A European training network for the discovery of neurotrophins small molecule mimetics as potential therapeutic agents for neurodegeneration and neuroinflammation” T. Calogeropoulou 

EuroNeurotrophin Press Release

ESR Fiches