Prof. Dame Pamela Shaw

B9:  University of Sheffield, United Kingdom
Sheffield Institute for Translational Neuroscience

Position
Founding Director, Sheffield Institute for Translational Neuroscience (SITraN)
Director, Sheffield NIHR Biomedical Research Centre for Translational Neuroscience
Vice President and Pro-Vice Chancellor Faculty of Medicine, Dentistry and Health
University of Sheffield

Background
Professor Shaw has devoted her career as a clinician scientist to translating basic research findings to the clinic in the field of neurodegeneration, especially ALS/MND. She is a world leading MND researcher. Achievements span: basic science into disease mechanisms; therapeutic target identification; evaluation and implementation of new symptomatic and neuroprotective therapies. Her research discoveries have improved life-expectancy and quality of life for MND patients.

Role in EuroNeurotrophin
Main Supervisor ESR 14
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Key Publications
Professor Shaw has authored over 480 publications amassing over 26,000 citations
https://www.researchgate.net/profile/Pamela_Shaw5

Selected recent publications:

• Nature Neuroscience  20:1225-1235 (2017)
  C9orf72 expansion disrupts ATM-mediated chromosomal break repair. C Walker, S Herranz-Martin, E Karyka, C Liao, K Lewis, W Elsayed, V Lukashchuk, S Chiang, S Ray, PJ Mulcahy, M Jurga, I Tsagakis, T Iannitti, J Chandran, I Coldicott, MK Hassan, A Higginbottom, PJ Shaw, GM Hautbergue, M Azzouz, SF El-Khamisy.
• Nature Communications  July  (2017) SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits. GM Hautbergue, L Castelli, L Ferraiuolo, A Sanchez-Martinez, J Cooper-Knock, A Higginbottom, Ya-Hui Lin, CS Bauer, JE Dodd, MA.Myszczynska, P Garneret, JS Chandran, E Karyka, MJ Stopford, EF Smith, J Kirby, K Meyer, BK Kaspar, AM Isaacs, KJ De Vos, K Ning, M Azzouz, AJ Whitworth,  PJ Shaw.
• Nature Reviews Disease Primers 3, 17071 (2017) Amyotrophic Lateral Sclerosis.  O Hardiman, A Al-Chalabi, A Chio, EM Corr, G Logroscino, W Robberecht, PJ Shaw, Z Simmons, L Van der Berg.
• Neurology 04 Oct (2017) Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials. RPA van Eijk, AR Jones, W Sproviero, A Shatunov, PJ Shae, PN Young, CE SHaw, G Mora, J Mandrioli et al.
• Human Molecular Genetics 26(6):1133-1145 (2017)  C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten. M Stopford, A Higginbottom, GM Hautbergue, J Cooper-Knock,  PJ Mulcahy, KJ De Vos, A Renton, H Pliner, A Calvo, A Chio, B Traynor, M Azzouz, PR Heath, ITALSGEN consortium, NeuroX consortium, J Kirby, PJ Shaw.