Positions Description
ESR1: Synthesis of dehydroepiandrosterone (DHEA) derivatives substituted by five or six membered-17-spiro substituents
ESR2: Synthesis of dehydroepiandrosterone (DHEA) derivatives substituted by three membered-17-spiro substituents
ESR3: Computer-aided molecular design
ESR4: Modelling of mechanistic effects of neurotrophin modulators
ESR5: Production of purified protein targets and x-ray crystal structure determination of target-ligand complexes
ESR6: In silico screening and Hit to lead development of small molecules neurotrophin receptors ligands
ESR7: Isolation of new natural neurotrophin mimetics from marine microorganisms
ESR8: Evaluation of small molecule neurotrophin mimetics in models of neurodegeneration and neuroinflammation
ESR9: Development of Human Cell-Based Models for study of Blood Brain Barrier Molecular Permeability
ESR10: Development of Human Cell-Based Models for Neurotrophic Therapeutic Testing
ESR11: Evaluation of activity on neurotrophin receptors and their role in signaling, in in vitro and in vivo neurodegenerative conditions, such as AD
ESR12: In vitro and in vivo effects of new synthetic and natural compounds on Neural Stem Cells and adult neurogenesis in AD
ESR13: Investigation of the potency of small molecule mimetics of neurotrophins to rescue the reduction in synapse number and the aberrant synapse proteome in mouse models of AD
ESR14: The neuroprotective effects of neurotrophins in novel in vitro and in vivo models of Motor Neurone Disease (ALS/MND)
- Host Institution: National Hellenic Research Foundation (NHRF), Athens, Greece
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st September 2018
- Planned secondments: Peakdale Molecular, United Kingdom (3 months), UNISI, Italy (2 months)
ESR2: Synthesis of dehydroepiandrosterone (DHEA) derivatives substituted by three membered-17-spiro substituents
- Host Institution: National Hellenic Research Foundation (NHRF), Athens, Greece
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st September 2018
- Planned secondments: HITS, Germany (1 month), TUD, Germany (2 months), VUA, The Netherlands (2 months)
ESR3: Computer-aided molecular design
- Host Institution: Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st September 2018
- Planned secondments: UNICAEN, France (2 months), UNISI, Italy (2 months), NKUA, Greece (1 month)
ESR4: Modelling of mechanistic effects of neurotrophin modulators
- Host Institution: Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st September 2018
- Planned secondments: UNISI, Italy (2 months), NHRF, Greece (1 month), TUD, Germany (2 months)
ESR5: Production of purified protein targets and x-ray crystal structure determination of target-ligand complexes
- Host Institution: University of Siena (UNISI), Siena, Italy
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st September 2018
- Planned secondments: Novartis (Hellas) S.A.C.I., Greece (2 months), FORTH, Greece (1 month), USFD, United Kingdom (2 months)
ESR6: In silico screening and Hit to lead development of small molecules neurotrophin receptors ligands
- Host Institution: Universite de Caen Normandie (UNICAEN), Caen, France
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st September 2018
- Planned secondments: UoC, Greece (1 month), Innoprot, Spain (3 months), NHRF, Greece (1 month)
ESR7: Isolation of new natural neurotrophin mimetics from marine microorganisms
- Host Institution: National and Kapodistrian University of Athens (NKUA), Athens, Greece
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st September 2018
- Planned secondments: USFD, United Kingdom (2 months), UoC, Greece (2 months), HITS, Germany (2 months)
ESR8: Evaluation of small molecule neurotrophin mimetics in models of neurodegeneration and neuroinflammation
- Host Institution: Technische Universitat Dresden (TUD), Dresden, Germany
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st September 2018
- Planned secondments: ACS, United Kingdom (1 month), FORTH, Greece (2 months), UNICAEN, France (2 months)
ESR9: Development of Human Cell-Based Models for study of Blood Brain Barrier Molecular Permeability
- Host Institution: AvantiCell Science Ltd (ACS), Scotland, UK
- Contract Duration: 12 Months renewable up to 26 months
- Start Date: 1st September 2019
- Planned secondments: NKUA, Greece (2 months), UNISI, Italy (2 months)
ESR10: Development of Human Cell-Based Models for Neurotrophic Therapeutic Testing
- Host Institution: AvantiCell Science Ltd (ACS), Scotland, UK
- Contract Duration: 12 Months renewable up to 26 months
- Start Date: 1st September 2019
- Planned secondments: VUA, The Netherlands (2 months), FORTH, Greece (2 months)
ESR11: Evaluation of activity on neurotrophin receptors and their role in signaling, in in vitro and in vivo neurodegenerative conditions, such as AD
- Host Institution: Foundation for Research and Technology Hellas (FORTH), Heraklion, Greece
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st September 2018
- Planned secondments: UNISI, Italy (2 months), ACS, United Kingdom (1 month), VUA, The Netherlands (2 months)
ESR12: In vitro and in vivo effects of new synthetic and natural compounds on Neural Stem Cells and adult neurogenesis in AD
- Host Institution: Foundation for Research and Technology Hellas (FORTH), Heraklion, Greece
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st September 2018
- Planned secondments: TUD, Germany (2 months), Innoprot, Spain (3 months)
ESR13: Investigation of the potency of small molecule mimetics of neurotrophins to rescue the reduction in synapse number and the aberrant synapse proteome in mouse models of AD
- Host Institution: VU University of Amsterdam (VUA), Amsterdam, Netherlands
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st December 2018
- Planned secondments: FORTH, Greece (2 months), TUD, Germany (2 months), Novartis (Hellas) S.A.C.I., Greece (2 months)
ESR14: The neuroprotective effects of neurotrophins in novel in vitro and in vivo models of Motor Neurone Disease (ALS/MND)
- Host Institution: University of Sheffield (USFD), Sheffield, United Kingdom
- Contract Duration: 12 Months renewable up to 36 months
- Start Date: 1st October 2018
- Planned secondments: NKUA, Greece (2 months), TUD, Germany (2 months), HITS, Germany (2 months)
