Ass. Prof. Ka Wan Li

B10: VU University of Amsterdam, Netherlands
Center for Neurogenomics and Cognitive Research

Position
Assistant Professor and Group leader of Neuroproteomics in Vrije Universiteit Amsterdam

Background
Ka Wan Li received his PhD degree from the Vrije Universiteit Amsterdam in 1993, and serves as Assistant Professor on the same year. He pioneered the use of mass spectrometry and nano-separation methodologies for neuroproteomics research since mid-ninety. His current research focus on the characterization of protein nano-machineries that underlies synapse function and plasticity, and study synapse/tissue proteome changes in neurodegenerative and neuropsychiatric disorders. State-of-the-art quantitative proteomics techniques are employed, using both human post-mortem brain tissues from patients and healthy controls, and the diverse mouse models of brain disorders.

Role in EuroNeurotrophin
Main Supervisor ESR10 & ESR 13

Key Publications

• Fainzilber M, Smit AB, Syed NI, Wildering WC, Hermann, van der Schors RC, Jiménez C, Li KW, van Minnen J, Bulloch AG, Ibáñez CF, Geraerts WP. (1996) CRNF, A Molluscan Neurotrophic Factor That Interacts With The P75 Neurotrophin Receptor. Science 274, 1540-1543
• von Engelhardt J, Mack V, Sprengel R, Kavenstock N, Li KW, Stern-Bach Y, Smit AB, Seeburg PH, Monyer H (2010) CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus. Science 327(5972):1518-22
• Li, K.W. (editor) Neuroproteomics (2012). Springer Protocols Neuromethods 57. Humana Press
• Hondius DC, van Nierop P, Li KW, Hoozemans JJ, van der Schors RC, van Haastert ES, van der Vies SM, Rozemuller AJ, Smit AB (2016) Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease. Alzheimers Dement. Jun;12(6):654-68. doi: 10.1016/j.jalz.2015.11.002.
• Gonzalez-Lozano MA, Klemmer P, Gebuis T, Hassan C, van Nierop P, RE, Smit AB, AB & Li KW. (2016) Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development Sci Rep 6, doi:10. 1038/srep35456